Description
CP-544326 is a potent selective prostaglandin EP (2) receptor agonist which is the active acid metabolite of the prodrug PF-04217329 (Taprenepag isopropyl). CP-544326 was found to be a potent and selective EP(2) agonist (IC(₅₀) = 10 nM; EC(₅₀) = 2.8 nM) whose corneal permeability and ocular bioavailability are significantly increased when the compound is dosed as the isopropyl ester prodrug, PF-04217329.
CP-544326 is a potent selective prostaglandin EP (2) receptor agonist which is the active acid metabolite of the prodrug PF-04217329 (Taprenepag isopropyl). CP-544326 was found to be a potent and selective EP(2) agonist (IC(₅₀) = 10 nM; EC(₅₀) = 2.8 nM) whose corneal permeability and ocular bioavailability are significantly increased when the compound is dosed as the isopropyl ester prodrug, PF-04217329.
Alternate Name/Synonyms: 2-(3-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)phenoxy)acetic acid; Taprenepag
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 752187-80-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₂N₄O₅S
Molecular Weight: 478.52
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent selective prostaglandin EP (2) receptor agonist
MDL Number: N/A
PubChem CID: 18376177
SMILES: C1=CC(=CC(=C1)OCC(=O)O)CN(CC2=CC=C(C=C2)N3C=CC=N3)S(=O)(=O)C4=CN=CC=C4
InChi: InChI=1S/C24H22N4O5S/c29-24(30)18-33-22-5-1-4-20(14-22)17-27(34(31,32)23-6-2-11-25-15-23)16-19-7-9-21(10-8-19)28-13-3-12-26-28/h1-15H,16-18H2,(H,29,30)
InChi Key: MFFBXYNKZHTCEY-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
