CP-547632 | B2056

CP-547,632 is a potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC₅₀ values of 11 and 9 nM, respectively. Displays anticancer activity.

CP-547,632 is a potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC₅₀ values of 11 and 9 nM, respectively. Displays anticancer activity.

B2056 | CP-547632 DataSheet

Alternate Name/Synonyms: 3-((4-bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide; PAN90806

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 252003-65-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₄BrF₂N₅O₃S

Molecular Weight: 532.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Apotent VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) inhibitor

MDL Number: N/A

PubChem CID: 9811611

SMILES: C1CCN(C1)CCCCNC(=O)NC2=C(C(=NS2)OCC3=C(C=C(C=C3F)Br)F)C(=O)N

InChi: InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30)

InChi Key: HXHAJRMTJXHJJZ-UHFFFAOYSA-N