CP-690550 | 1622

Cell-permeable. A Janus Kinase 3 (JAK3) inhibitor. Displays greater antiproliferative and pro-apoptotic activity against murine multipotent factor-dependent cell Patersen-erythropoietin receptor (FDCP-EpoR) cells harboring JAK2(V617F) compared with JAK2(WT).

CP-690550 is a cell-permeable, Janus Kinase 3 (JAK3) inhibitor. Displays greater antiproliferative and pro-apoptotic activity against murine multipotent factor-dependent cell Patersen-erythropoietin receptor (FDCP-EpoR) cells harboring JAK2(V617F) compared with JAK2(WT).

1622 | CP-690550 DataSheet

Alternate Name/Synonyms: Tasocitinib; Tofacitinib

Appearance: Off-white to pale yellow solid

Formulation: N/A

CAS Number: 477600-75-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₂₀N₆O

Molecular Weight: 312.37

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (100 mg/ml) of EtOH (100 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A JAK3 inhibitor

MDL Number: MFCD11616529

PubChem CID: 9818231

SMILES: CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N

InChi: InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)

InChi Key: UJLAWZDWDVHWOW-UHFFFAOYSA-N