CPI-1205 | B2509

CPI-1205 is a highly potent (biochemical IC₅₀ = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of the histone lysine methyltransferase EZH2 (biochemical IC₅₀ = 0.002 μM, cellular EC₅₀ = 0.032 μM). Upon oral administration, CPI-1205 selectively inhibits the activity of both wild-type and mutated forms of EZH2.

CPI-1205 is a highly potent (biochemical IC₅₀ = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of the histone lysine methyltransferase EZH2 (biochemical IC₅₀ = 0.002 μM, cellular EC₅₀ = 0.032 μM). Upon oral administration, CPI-1205 selectively inhibits the activity of both wild-type and mutated forms of EZH2.

B2509 | CPI-1205 DataSheet

Alternate Name/Synonyms: N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide; CPI1205

Appearance: Crystalline solid

Formulation:

CAS Number: 1621862-70-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₃F₃N₄O₃

Molecular Weight: 518.57

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >100 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An EZH2 inhibitor

MDL Number:

PubChem CID: 78320408

SMILES: CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(N(C3=CC=CC=C32)C(C)C4CCN(CC4)CC(F)(F)F)C)OC

InChi: InChI=1S/C27H33F3N4O3/c1-16-13-23(37-4)21(25(35)32-16)14-31-26(36)24-18(3)34(22-8-6-5-7-20(22)24)17(2)19-9-11-33(12-10-19)15-27(28,29)30/h5-8,13,17,19H,9-12,14-15H2,1-4H3,(H,31,36)(H,32,35)/t17-/m1/s1

InChi Key: HPODOLXTMDHLLC-QGZVFWFLSA-N