CPI-203 | 9404

CPI-203 is an analog of (+)-JQ1 (Cat. No. 2070). Acts as a BET bromodomain inhibitor. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.CPI-203 arrests the growth of leukemic T cells in vitro (EC₅₀ = 91 nM) and rapidly suppresses leukemia burden in mice.

CPI-203 is an analog of (+)-JQ1 (Cat. No. 2070). Acts as a BET bromodomain inhibitor. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.CPI-203 arrests the growth of leukemic T cells in vitro (EC₅₀ = 91 nM) and rapidly suppresses leukemia burden in mice.

9404 | CPI-203 DataSheet

Alternate Name/Synonyms: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

Appearance: White solid

Formulation: N/A

CAS Number: 1446144-04-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₈ClN₅OS

Molecular Weight: 399.9

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A BET bromodomain inhibitor

MDL Number: N/A

PubChem CID: 71291068

SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)Cl)C

InChi: InChI=1S/C19H18ClN5OS/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)22-14(8-15(21)26)18-24-23-11(3)25(18)19/h4-7,14H,8H2,1-3H3,(H2,21,26)/t14-/m0/s1

InChi Key: QECMENZMDBOLDR-AWEZNQCLSA-N