CPI-455 hydrochloride | B3254

CPI-455 hydrochloride is a potent and selective inhibitor of KDM5 demethylases. which reduces survival of drug-tolerant cancer cells. CPI-455 binds to the demethylase active site and selectively inhibits KDM5A-D (IC50s = 2-10 nM) over KDM2-4, 6, and 7 family members (IC50s = 1 to >25 μM). It increases histone H3K4me2/3 methylation in vitro and decreases the number of drug-tolerant cells in PC9 non-small cell lung, M14 melanoma, and SKBR3 breast cancer cell populations.

CPI-455 hydrochloride is a potent and selective inhibitor of KDM5 demethylases. which reduces survival of drug-tolerant cancer cells. CPI-455 binds to the demethylase active site and selectively inhibits KDM5A-D (IC50s = 2-10 nM) over KDM2-4, 6, and 7 family members (IC50s = 1 to >25 μM). It increases histone H3K4me2/3 methylation in vitro and decreases the number of drug-tolerant cells in PC9 non-small cell lung, M14 melanoma, and SKBR3 breast cancer cell populations.

B3254 | CPI-455 hydrochloride DataSheet

Alternate Name/Synonyms: CPI455 HCl 7-oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile;hydrochloride

Appearance: Crystalline solid

Formulation:

CAS Number: 2095432-28-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₅ClN₄O

Molecular Weight: 314.77

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective inhibitor of KDM5 demethylases

MDL Number:

PubChem CID: 129896721

SMILES: CC(C)C1=C(N=C2C(=CNN2C1=O)C#N)C3=CC=CC=C3.Cl

InChi: InChI=1S/C16H14N4O.ClH/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21;/h3-7,9-10,18H,1-2H3;1H

InChi Key: SNODPNXOTKXHHH-UHFFFAOYSA-N