CPLX1 Antibody (Center) [APR11652G]

CPLX1 Antibody (Center) [APR11652G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This CPLX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-60 amino acids from the Central region of human CPLX1.

Cellular Localisation: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P63040}. Perikaryon {ECO:0000250|UniProtKB:P63040}. Cell junction, synapse, presynapse {ECO:0000250|UniProtKB:P63040}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250|UniProtKB:P63040}

Molecular Weight: 15030

Clone: Polyclonal

Gene Name: CPLX1

Gene ID: 10815

Function: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414) . Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414) . Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.

Summary: Tissue Location: Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Complexin-1, Complexin I, CPX I, Synaphin-2, CPLX1