CPLX2 Antibody (Center) [APR11653G]

CPLX2 Antibody (Center) [APR11653G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This CPLX2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from the Central region of human CPLX2.

Cellular Localisation: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84087}. Cell junction, synapse, presynapse {ECO:0000250|UniProtKB:P84087}. Nucleus {ECO:0000250|UniProtKB:P84087} Perikaryon {ECO:0000250|UniProtKB:P84087}. Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. {ECO:0000250|UniProtKB:P84087}

Molecular Weight: 15394

Clone: Polyclonal

Gene Name: CPLX2

Gene ID: 10814

Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity) .

Summary: Tissue Location: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Complexin-2, Complexin II, CPX II, Synaphin-1, CPLX2