CPTH2 (hydrochloride) | B2815

CPTH2 (hydrochloride) is an inhibitor of Histone Acetyltransferase (HAT) activity of Gcn5. Gcn5 acetylates histones H2B and H3. CPTH2 inhibited HAT reaction in vitro and it decreased acetylation of histone H3 at the specific H3-K14 site at micromolar concentrations. CPTH2 inhibited the Gcn5p dependent network. CPTH2 reduced the growth of adenovirus by inhibiting the lysine acetyltransferase activity of Gcn5.

CPTH2 (hydrochloride) is an inhibitor of Histone Acetyltransferase activity of Gcn5. Gcn5 acetylates histones H2B and H3. CPTH2 inhibited HAT reaction in vitro and it decreased acetylation of histone H3 at the specific H3-K14 site at micromolar concentrations. CPTH2 inhibited the Gcn5p dependent network. CPTH2 reduced the growth of adenovirus by inhibiting the lysine acetyltransferase activity of Gcn5.

B2815 | CPTH2 (hydrochloride) DataSheet

Alternate Name/Synonyms: 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole hydrochloride, Histone Acetyltransferase Inhibitor IV, CPTH2

Appearance: Crystalline solid

Formulation:

CAS Number: 2108899-91-6

Structure Available?: True

Peptide sequence:

Salt Form: True

Molecular Formula: C₁₄H₁₅Cl₂N₃S

Molecular Weight: 328.26

Cell-Permeable?: True

Purity: ≥95%

Solubilities: 5 mg/ml in ethanol and DMF in 0, 16 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of Histone Acetyltransferase activity of Gcn5

MDL Number:

PubChem CID:

SMILES: ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Cl

InChi: InChI=1S/C14H14ClN3S.ClH/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12;/h5-9H,1-4H2,(H,16,18);1H

InChi Key: ODVWZAKKCNHATB-UHFFFAOYSA-N