CRANAD-2 | 2699

GRANAD-2 is a near-infrared Aβ plaque-specific fluorescent probe penetrating the blood brain barrier and label senile plaques specifically in vivo. Upon interacting with Aβ aggregates, CRANAD-2 displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. CRANAD -2 has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.

GRANAD-2 is a near-infrared Aβ plaque-specific fluorescent probe penetrating the blood brain barrier and label senile plaques specifically in vivo. Upon interacting with Aβ aggregates, CRANAD-2 displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield.

2699 | CRANAD-2 DataSheet

Alternate Name/Synonyms: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron

Appearance: Dark blue to black solid

Formulation: N/A

CAS Number: 1193447-34-5

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅BF₂N₂O₂

Molecular Weight: 410.26

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 2 mg/ml with slight warming)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An amyloid β (Aβ ) plaque-specific fluorescent probe

MDL Number: N/A

PubChem CID: N/A

SMILES: CN(C)C1=CC=C(/C=C/C(/C=C(/C=C/C2=CC=C(N(C)C)C=C2)OB(F)F)=O)C=C1>>

InChi: InChI=1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22(29)17-23(30-24(25)26)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3/b15-9+,16-10+,23-17-

InChi Key: REYKHNSZPNPCFO-HCYHKVCZSA-N