CREB3 Antibody (N-term) [AMM05358G]

CREB3 Antibody (N-term) [AMM05358G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CREB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human CREB3.

Cellular Localisation: [Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein {ECO:0000255, ECO:0000269|PubMed:12138176}. Golgi apparatus. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756) . Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900) . Colocalizes with CANX, CCR1, HCFC1 in the ER membrane (PubMed:10623756) . [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB) .

Molecular Weight: 41379

Clone: Polyclonal

Gene Name: CREB3

Gene ID: 10488

Function: Endoplasmic reticulum (ER) -bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180) . Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180) . Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN- 1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613) . Associates with chromatin to the HERPUD1 promoter (PubMed:16940180) . Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613) .

Summary: Tissue Location: Ubiquitously expressed (PubMed:9271389, PubMed:19779205) . Expressed in dendritic cells (DC) . Weakly expressed in monocytes (at protein level) (PubMed:20546900)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Cyclic AMP-responsive element-binding protein 3, CREB-3, cAMP-responsive element-binding protein 3, Leucine zipper protein, Luman, Transcription factor LZIP-alpha, Processed cyclic AMP-responsive element-binding protein 3, N-terminal Luman, Transcriptionally active form, CREB3, LZIP