Crenolanib | 9679

Crenolanib is a highly selective and potent FLT3 tyrosine kinase inhibitor (TKI) with activity against the internal tandem duplication (FLT3/ITD) mutants and the FLT3/D835 point mutants. Also displays inhibitory activity against PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells.

Crenolanib is a highly selective and potent FLT3 tyrosine kinase inhibitor (TKI) with activity against the internal tandem duplication (FLT3/ITD) mutants and the FLT3/D835 point mutants. Also displays inhibitory activity against PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells.

9679 | Crenolanib DataSheet

Alternate Name/Synonyms: 1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP-868596; ARO 002

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 670220-88-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₉N₅O₂

Molecular Weight: 443.54

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly selective and potent FLT3 tyrosine kinase inhibitor

MDL Number: N/A

PubChem CID: 10366136

SMILES: CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4

InChi: InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3

InChi Key: DYNHJHQFHQTFTP-UHFFFAOYSA-N