CRK Antibody (phospho-S41)| F40128-0.08ML

CRK Antibody (phospho-S41)| F40128-0.08ML | Gentaur UK, US & Europe Distribution

Background: CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat

Application: DB, ELISA

Application Details: Dot blot: 1:500

Application Note: Titration of the phospho-CRK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This phospho-CRK antibody is available for research use only.

Purity: Antigen affinity

Immunogen: This phospho-CRK antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS41 of human CRK.

Storage: Aliquot the phospho-CRK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A