CRKL Antibody, KO Validated | 14-122

CRKL Antibody, KO Validated | 14-122 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CRKL (NP_005198.1) .

Research Area: Cancer, Immunology, Neuroscience, Signal Transduction

Tested Application: WB, IF

Application: WB: 1:500 - 1:2000
IF: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: LO2

Positive Control 2: Jurkat

Positive Control 3: SKOV3

Positive Control 4: Mouse brain

Positive Control 5: Rat heart

Positive Control 6: N/A

Molecular Weight: Observed: 37kDa

Validation: Antibody is Knockout validated.

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: CRKL, v-crk sarcoma virus CT10 oncogene homolog (avian) -like, v-crk avian sarcoma virus CT10 oncogene homolog-like,

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.