CRT0066101 | B1847

CRT0066101 is a potent inhibitor of protein kinase D (PKD). It inhibits all PKD isoforms (IC₅₀ values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). It displays selectivity for PKD against a panel of >90 protein kinases, including PKCα, MEK, ERK, c-Raf and c-Src.

CRT0066101 is a potent inhibitor of protein kinase D (PKD). It inhibits all PKD isoforms (IC₅₀ values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). It displays selectivity for PKD against a panel of >90 protein kinases, including PKCα, MEK, ERK, c-Raf and c-Src.

B1847 | CRT0066101 DataSheet

Alternate Name/Synonyms: 2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1883545-60-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₂₂N₆O.2HCl

Molecular Weight: 411.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent protein kinase D (PKD) inhibitor

MDL Number: N/A

PubChem CID: 126970672

SMILES: CCC(CNC1=CC=NC(=C2C=C(C=CC2=O)C3=CN(N=C3)C)N1)N.Cl.Cl

InChi: InChI=1S/C18H22N6O.2ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;;/h4-9,11,14,21,23H,3,10,19H2,1-2H3;2*1H/b18-15+;;/t14-;;/m1../s1

InChi Key: YABREXUEJVISSM-ILDIYEGTSA-N