CRTR1 Antibody (N-term) [APR15607G]

CRTR1 Antibody (N-term) [APR15607G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This CRTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human CRTR1.

Cellular Localisation: Nucleus.

Molecular Weight: 54627

Clone: Polyclonal

Gene Name: TFCP2L1

Gene ID: 29842

Function: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118) . With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity) . Required for normal duct development in the salivary gland and kidney (By similarity) . Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid- base and salt-water homeostasis, respectively (By similarity) . Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity) . Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity) . JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity) . Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity) . Modulates the placental expression of CYP11A1 (PubMed:10644752) .

Summary: Tissue Location: Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC, IF, IHC-P-Leica

Dilution: IHC-P-Leica--1:500 IF--1:25 FC--1:25 WB--1:2000

Synonyms: Transcription factor CP2-like protein 1, CP2-related transcriptional repressor 1, CRTR-1, Transcription factor LBP-9, TFCP2L1, CRTR1, LBP9