CRYAB Antibody [APG02805G]

CRYAB Antibody [APG02805G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H, M, Rat

Specificity: This CRYAB antibody is generated from a mouse immunized with a recombination protein from the human region of human CRYAB.

Cellular Localisation: Cytoplasm. Nucleus Secreted. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326) Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373) . Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059)

Molecular Weight: 20159

Clone: Monoclonal

Gene Name: CRYAB (HGNC:2389)

Gene ID: 1410

Function: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

Summary: Tissue Location: Lens as well as other tissues (PubMed:838078, PubMed:2387586) . Expressed in myocardial tissue (PubMed:28493373)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Alpha-crystallin B chain, Alpha (B) -crystallin, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, CRYAB, CRYA2