CTCF polyclonal Antibody | BS90338

CTCF polyclonal Antibody | BS90338 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat, Zebrafish

Application: WB ICC/IF IHC IP

Application Range: WB:1:500-1:1,000 ICC:1:100-1:500 IHC:1:50-1:200 IP:1:50-1:100

Background: CTCF belongs to the zinc finger transcription factor family, and it recognizes unusually long and remarkably divergent DNA target sequences to influence expression of many various genes. The DNA-binding domain of CTCF is composed of 11 Zn fingers including 10 that are of C2H2 class, and 1 that is of C2HC class, and they are highly conserved between vertebrate species. CTCF functions as a repressor of the c-myc gene and as a regulator of lysozyme gene expression. In addition, CTCF associates with the essential activator domain in the promotor region of the amyloid beta-protein precursor (APP) gene to activate transcription of APP. Expression of CTCF up-regulates APP expression and thereby, enhances synapse formations between primary neurons during development. CTCF is ubiquitously expressed and localized to the nucleus. During terminal differentiation, CTCF is negatively regulated by differential phosphorylation and also by decreases in CTCF mRNA and protein expression.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CTCF polyclonal Antibody detects endogenous levels of CTCF protein.

Molecular Weight: 140/83 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CTCF, 11 zinc finger protein, 11 zinc finger transcriptional repressor, 11-zinc finger protein, CCCTC binding factor (zinc finger protein), CCCTC binding factor, CCCTC-binding factor, Ctcf, CTCF, CTCFL paralog, MRD21, Transcriptional repressor CTCF,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: