CTNND2 Antibody (C-term) [APR11692G]

CTNND2 Antibody (C-term) [APR11692G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This CTNND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1131-1159 amino acids from the C-terminal region of human CTNND2.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:O35927}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O35927}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35116}. Perikaryon

Molecular Weight: 132656

Clone: Polyclonal

Gene Name: CTNND2

Gene ID: 1501

Function: Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484) . Involved in the regulation of Wnt signaling (PubMed:25807484) . It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity) . Functions as a transcriptional activator when bound to ZBTB33 (By similarity) . May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.

Summary: Tissue Location: Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP