CTPS (K109) polyclonal Antibody | BS2871

CTPS (K109) polyclonal Antibody | BS2871 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: CTPS (cytidine-5-prime-triphosphate synthase) is a 591 amino acid protein that contains one glutamine amidotransferase type-1 domain and is involved in pyrimidine metabolism. CTPS catalyzes the ATP-dependent conversion of UTP to CTP, a rate-limiting reaction that requires either ammonia or L-glutamine as a nitrogen source. Via its catalytic activity, CTPS plays an important role in the synthesis of nucleic acids and is crucial for proper cell growth and development. The function of CTPS is regulated by a variety of mechanisms, including phosphorylation by protein kinase C (PKC), an event that can either stimulate or inhibit CTPS activity. The gene encoding CTPS is located in a region on chromosome 1 that is often associated with the progression of several tumor types, suggesting a possible role for CTPS in tumorigenesis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CTPS (K109) polyclonal Antibody detects endogenous levels of CTPS protein.

Molecular Weight: ~ 67 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CTP synthase 1; CTP synthetase 1; UTP--ammonia ligase 1; CTPS1; CTPS

Immunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human CTPS.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: