CTRP6 Antibody [256-E] | 36-094

CTRP6 Antibody [256-E] | 36-094 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: Recombinant human CTRP6 (globular domain-less) .

Research Area: Cancer, Innate Immunity, Obesity

Tested Application: E, WB

Application: ELISA: (direct or indirect: 1:200-1:500) . Immunohistochemistry (paraffin sections) : 1:200. Western blot: (1:200-1:500 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature) . Optimal conditions should be determined individually for each application.

Specificiy: Recognizes the N-terminal half of human CTRP6 full-length protein. Detects bands of ~16kDa and ~32kDa by Western blot.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: 256-E

Isotype: IgG1, kappa

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

Concentration: 0.5 mg/ml

Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.

Alternate Name: Complement C1q Tumor Necrosis Factor-related Protein 6; C1QTNF6; C1qTNF-related Protein 6; ZACRP 6

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CTRP6 mediates the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in skeletal muscle cells, subsequently mediating glycogen accumulation and fatty acid oxidation. It induces the expression of the potent anti-inflammatory cytokine IL-10 in macrophages. CTRP6 may be a potential serum marker for hepatocellular carcinoma, contributing to tumor angiogenesis by activating the Akt pathway. CTRP6 was also shown to be associated with obesity, type 1 diabetes mellitus (T1D) , vitiligo (depigmentation of the skin) and ASFV (African Swine Fever Virus) . CTRP6 forms homotrimers and higher-order oligomers and it may also form heteromeric complexes with CTRP1. May be involved in kidney inflammation.