CTSC Antibody | 23-559

CTSC Antibody | 23-559 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-134 of human CTSC (NP_001805.3) .

Research Area: Cell Cycle

Tested Application: WB, IHC

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:100

Specificiy: N/A

Positive Control 1: NCI-H460

Positive Control 2: 293T

Positive Control 3: SW620

Positive Control 4: HL-60

Positive Control 5: HeLa

Positive Control 6: Mouse liver

Molecular Weight: Observed: 70kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: CTSC, cathepsin C, CPPI, DPP1, DPPI, HMS, JP, JPD, PALS, PLS, DPP-I, OTTHUMP00000235623, OTTHUMP00000235624, OTTHUMP00000235625, OTTHUMP00000235627, cathepsin J, dipeptidyl peptidase 1, dipeptidyl peptidase I, dipeptidyl transferase, dipeptidyl-peptidase

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.