CTSD (heavy chain) Antibody (Center) [APR04698G]

CTSD (heavy chain) Antibody (Center) [APR04698G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CTSD (heavy chain) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 241-273 amino acids from the Central region of human CTSD (heavy chain) .

Cellular Localisation: Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380)

Molecular Weight: 44552

Clone: Polyclonal

Gene Name: CTSD

Gene ID: 1509

Function: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034) . Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Summary: Tissue Location: Expressed in the aorta extracellular space (at protein level) (PubMed:20551380) . Expressed in liver (at protein level) (PubMed:1426530) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD