CTTN Antibody (Center) [APR03855G]

CTTN Antibody (Center) [APR03855G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.

Cellular Localisation: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendrite. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, dendritic spine. Cytoplasm, cell cortex Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity) . Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity) In the presence of CTTNBP2, localizes at the cell cortex (By similarity) . In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity) . Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity) {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2}

Molecular Weight: 61586

Clone: Polyclonal

Gene Name: CTTN

Gene ID: 2017

Function: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879) . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity) . Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity) . Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290) . Plays a role in focal adhesion assembly and turnover (By similarity) . In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1- phosphate (S1P) -mediated endothelial cell (EC) barrier enhancement (PubMed:20861316) . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782) . Plays a role in receptor- mediated endocytosis via clathrin-coated pits (By similarity) . Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1