CUDC-101 | 1966

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC₅₀ values of 4.4, 2.4, and 15.7 nM, respectively. Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

CUDC-101 is a potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC₅₀ values of 4.4, 2.4, and 15.7 nM, respectively. Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

1966 | CUDC-101 DataSheet

Alternate Name/Synonyms: 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide

Appearance: White solid

Formulation: N/A

CAS Number: 1012054-59-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₆N₄O₄

Molecular Weight: 434.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent inhibitor of HDACs and receptor tyrosine kinases

MDL Number: MFCD15528940

PubChem CID: 24756910

SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO

InChi: InChI=1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20 (19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7, 11-12H2,2H3,(H,28,29)(H,25,26,27)

InChi Key: PLIVFNIUGLLCEK-UHFFFAOYSA-N