CUDC-305 | 9653

CUDC-305 is a potent inhibitor of Heat Shock Proteins, displaying high affinity for HSP90α/β (IC₅₀ = 100 nM) and HSP90 complex derived from cancer cells (IC₅₀ = 48.8 nM).

CUDC-305 is a potent inhibitor of Heat Shock Proteins, displaying high affinity for HSP90α/β (IC₅₀ = 100 nM) and HSP90 complex derived from cancer cells (IC₅₀ = 48.8 nM).

9653 | CUDC-305 DataSheet

Alternate Name/Synonyms: 2-((6-(dimethylamino)benzo[d][1,3]dioxol-5-yl)thio)-1-(2-(neopentylamino)ethyl)-1H-imidazo[4,5-c]pyridin-4-amine; Debio-0932

Appearance: White solid

Formulation: N/A

CAS Number: 1061318-81-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₃₀N₆O₂S

Molecular Weight: 442.58

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of Heat Shock Proteins, displaying high affinity for HSP90α/β

MDL Number: N/A

PubChem CID: 44156921

SMILES: CC(C)(C)CNCCN1C2=C(C(=NC=C2)N)N=C1SC3=CC4=C(C=C3N(C)C)OCO4

InChi: InChI=1S/C22H30N6O2S/c1-22(2,3)12-24-8-9-28-14-6-7-25-20(23)19(14)26-21(28)31-18-11-17-16(29-13-30-17)10-15(18)27(4)5/h6-7,10-11,24H,8-9,12-13H2,1-5H3,(H2,23,25)

InChi Key: RVJIQAYFTOPTKK-UHFFFAOYSA-N