CVT-10216 | B2765

CVT-10216 is a potent, selective, and reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT-10216 has been reported to reduce excessive alcohol drinking in alcohol-preferring rats and to prevent self-administration of alcohol in Long-Evans rats.

CVT-10216 is a potent, selective, and reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT-10216 has been reported to reduce excessive alcohol drinking in alcohol-preferring rats and to prevent self-administration of alcohol in Long-Evans rats.

B2765 | CVT-10216 DataSheet

Alternate Name/Synonyms: 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid,CVT10216,GS-455534

Appearance: Off-white solid

Formulation:

CAS Number: 1005334-57-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₁₉NO₇S

Molecular Weight: 465.48

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >40 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective ALDH2 inhibitor

MDL Number:

PubChem CID: 23661666

SMILES: CS(=O)(=O)NC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)OCC4=CC(=CC=C4)C(=O)O

InChi: InChI=1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28)

InChi Key: YYOOFJZTRCPVFD-UHFFFAOYSA-N