CVT-313 | B1137

CVT-313 is a potent and selective inhibitor of CDK2 (cyclin dependent kinase 2) arresting cell growth with IC₅₀ ranging from 1.25 to 20 µM. The Inhibition is competitive with respect to ATP (Ki = 95 nM). CVT-313 has no effect on other, nonrelated ATP-dependent serine/threonine kinases.

CVT-313 is a potent and selective inhibitor of CDK2 (cyclin dependent kinase 2) arresting cell growth with IC₅₀ ranging from 1.25 to 20 µM. The Inhibition is competitive with respect to ATP (Ki = 95 nM). CVT-313 has no effect on other, nonrelated ATP-dependent serine/threonine kinases.

B1137 | CVT-313 DataSheet

Alternate Name/Synonyms: 2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine

Appearance: White Solid

Formulation: N/A

CAS Number: 199986-75-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₈N₆O₃

Molecular Weight: 400.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective inhibitor of CDK2 (cyclin dependent kinase 2)

MDL Number: MFCD06411412

PubChem CID: 6918386

SMILES: CC(C)N1C=NC2=C1N=C(N=C2NCC3=CC=C(C=C3)OC)N(CCO)CCO

InChi: 1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)

InChi Key: NQVIIUBWMBHLOZ-UHFFFAOYSA-N