CWHM-12 | B1251

CWHM-12 a potent small molecule inhibitor of αV integrins with IC₅₀s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8. It displays less potency on αvβ5 (IC₅₀ = 61 nM) and on inhibition on αIIbβ3/α2β1/α10β1.

CWHM-12 a potent small molecule inhibitor of αV integrins with IC₅₀s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8. It displays less potency on αvβ5 (IC₅₀ = 61 nM) and on inhibition on αIIbβ3/α2β1/α10β1.

B1251 | CWHM-12 DataSheet

Alternate Name/Synonyms: (3S)-N-[3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino]benzoyl]glycyl-3-[3-bromo-5-(1,1-dimethylethyl)phenyl]-β-alanine

Appearance: White Solid

Formulation: N/A

CAS Number: 1564286-55-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₃₂BrN₅O₆

Molecular Weight: 590.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An α(v) integrin inhibitor and known to suppress all 5 alpha V integrins

MDL Number:

PubChem CID: 72949858

SMILES: CC(C)(C)C1=CC(=CC(=C1)C(CC(=O)O)NC(=O)CNC(=O)C2=CC(=CC(=C2)O)NC3=NCC(CN3)O)Br

InChi: InChI=1S/C26H32BrN5O6/c1-26(2,3)16-4-14(5-17(27)8-16)21(10-23(36)37)32-22(35)13-28-24(38)15-6-18(9-19(33)7-15)31-25-29-11-20(34)12-30-25/h4-9,20-21,33-34H,10-13H2,1-3H3,(H,28,38)(H,32,35)(H,36,37)(H2,29,30,31)/t21-/m0/s1

InChi Key: YDHAGPCZRFQPOI-NRFANRHFSA-N