CX-6258 | 2851

CX-6258 is a potent pan-Pim kinases inhibitor (IC₅₀ values of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively). CX-6258 exhibits in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models.

CX-6258 is a potent pan-Pim kinases inhibitor (IC₅₀ values of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively).

2851 | CX-6258 DataSheet

Alternate Name/Synonyms: (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one

Appearance: White solid

Formulation: N/A

CAS Number: 1202916-90-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₄ClN₃O₃

Molecular Weight: 461.94

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent pan-Pim kinase inhibitor

MDL Number: N/A

PubChem CID: 44545852

SMILES: CN1CCCN(CC1)C(=O)C2=CC=CC(=C2)C3=CC=C(O3)C=C4C5=C(C=CC(=C5)Cl)NC4=O

InChi: InChI=1S/C26H24ClN3O3/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31)/b22-16+

InChi Key: KGBPLKOPSFDBOX-CJLVFECKSA-N