CXCL14/BRAK, human recombinant | 4278

Human Chemokine (C-X-C motif) ligand 14(hCXCL14),also known as breast and kidney-expressed chemokine (BRAK), MIP-2 gamma, kidney-expressed chemokine (KEC), and B cell and monocyte-activating chemokine (BMAC), is a CXC chemokine constitutively expressed in certain normal tissues but is reduced or absent from many established tumor cell lines and human cancers. CXCL14 is known to be a chemo-attractant for monocyte and dendritic cells. CXCL14 inhibits angiogenesis and exhibits antimicrobial activities. Mature human and mouse CXCL14 differ by only 2 residues.

4278 | CXCL14/BRAK human recombinant DataSheet

Biomolecule/Target: CXCL-14

Synonyms: Chemokine BRAK, MIP-2G, Small-inducible cytokine B14

Alternates names: Cartilage-derived morphogenetic protein-1, CDMP-1, LAP4, SYNS2, GDF-5, Radotermin, CDMP1, GDF5, Growth differentiation factor 5, BMP-14

Taglines: Chemoattractant for monocytes and dendritic cells

NCBI Gene ID #: 8200

NCBI Gene Symbol: GDF5

Gene Source: Human

Accession #: X80915

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: 95%

Assay #2: HPLC

Endotoxin Level: <0.1 ng/g (1 IEU/g)

Activity (Specifications/test method): N/A

Biological activity: The ED as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1-2 µg/ml.

Results: 1.0-10.0 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 13.6 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from a 0.2 m filtered solution of 20 mM Tris HCl and 1 M NaCl, pH 8.5.

Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in HO containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.

Amino acid sequence: N/A