CXXC5 Antibody (N-Term) [ApR04949G]

CXXC5 Antibody (N-Term) [ApR04949G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CXXC5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 47-80 amino acids from human CXXC5.

Cellular Localisation: Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q5XIQ3} Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250|UniProtKB:Q5XIQ3}

Molecular Weight: 32977

Clone: Polyclonal

Gene Name: CXXC5

Gene ID: 51523

Function: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity) . Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788) . May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788) . Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: CXXC-type zinc finger protein 5, CF5, Putative MAPK-activating protein PM08, Putative NF-kappa-B-activating protein 102, Retinoid-inducible nuclear factor, RINF, CXXC5