CYC-116 | B1936

CYC116 is a potent inhibitor of Aurora A and B with Ki value of 8 nM and 9.2 nM, respectively. It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 displays broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC₅₀ value of 0.54 µM (range = 0.09 – 1.6 µM).

CYC116 is a potent inhibitor of Aurora A and B with Ki value of 8 nM and 9.2 nM, respectively. It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 displays broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC₅₀ value of 0.54 µM (range = 0.09 – 1.6 µM).

B1936 | CYC-116 DataSheet

Alternate Name/Synonyms: 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 693228-63-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₀N₆OS

Molecular Weight: 368.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of Aurora A and B

MDL Number: N/A

PubChem CID: 6420138

SMILES: CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4

InChi: InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23)

InChi Key: GPSZYOIFQZPWEJ-UHFFFAOYSA-N