Cyclin H monoclonal Antibody | MB0018

Cyclin H monoclonal Antibody | MB0018 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Application: WB IP

Application Range: WB: 1:1000 IP: 1:50~1:200

Background: Cyclin H belongs to the highly conserved cyclin family, and are regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin H forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, and thus functions as a CDK-activating kinase (CAK) . Cyclin H and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of CCNH and does not cross-react with related proteins

Molecular Weight: Predicted band size:38KDa Observed band size:38KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cyclin-H; MO15-associated protein; p34; p37; CCNH

Immunogen: Recombinant full length Human Cyclin H.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Cell Cycle G2 M DNA Damage Signaling Pathway,