Cycloheximide (100 mM) | 1041

A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents.

Cyclohexcimide is very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step.

1041 | Cycloheximide (100 mM) DataSheet

Alternate Name/Synonyms: 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A

Appearance: Liquid

Formulation: DMSO ( 100 mM)

CAS Number: 66-81-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₃NO₄

Molecular Weight: 281.35

Cell-Permeable?: Yes

Purity: >95%

Solubilities: N/A

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A protein synthesis inhibitor

MDL Number: MFCD00082346

PubChem CID: 6197

SMILES: CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C

InChi: InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19) 7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChi Key: YPHMISFOHDHNIV-FSZOTQKASA-N