Cyclooxygenase 2, Human Recombinant (Insect) | P1344

Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, EC 1.14.99.1), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. COX consists of two isoforms, COX-1 and COX-2. The COX enzymes, membrane-associated heme proteins that have cyclooxygenase and peroxidase activities, are targets of NSAID (non-steroidal anti-inflammatory drugs). COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2.

P1344 | Cyclooxygenase 2 Human Recombinant Insect DataSheet

Biomolecule/Target: COX-2

Synonyms: COX-2, Prostaglandin G/H synthase 2 (PGHS-2)

Alternates names: OB Protein, Obesity Protein, OBS, Obesity factor, HuB219, OB receptor, CD_antigen=CD295

Taglines: Catalyzes the conversion of arachidonic acid to prostaglandin H2

NCBI Gene ID #: 3952

NCBI Gene Symbol: LEP

Gene Source: Human

Accession #: P48357

Recombinant: Yes

Source: E.coli

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): Measured by its ability to generates 1.0 µmol of hydrogen peroxide from arachidonic acid per minute at pH 8.0, 25°C.

Biological activity: N/A

Results: 100 mU/mg

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: N/A

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized in proprietary buffer

Reconstitution Instructions: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 g/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles

Amino acid sequence: Phe22-Asp839