Cyclopamine | 1578

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins.

1578 | Cyclopamine DataSheet

Alternate Name/Synonyms: 11-deoxojervine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 4449-51-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₄₁NO₂

Molecular Weight: 411.62

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: DMSO (4 mg/ml) and EtOH (5 mg/ml)

Handling: Teratogen!

Country of Origin: USA

Tag Line: A hedgehog signaling inhibitor

MDL Number: MFCD01735266

PubChem CID: 442972

SMILES: CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1

InChi: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1

InChi Key: QASFUMOKHFSJGL-LAFRSMQTSA-N