Cyclopamine-KAAD | 1910

Cell-permeable. A synthetic derivative of the natural product Cyclopamine (Cat. No. 1578-5) that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling (IC₅₀ = 20 nM in the Shh-LIGHT2 assay).

Cyclopamine-KAAD is a synthetic derivative of the natural product Cyclopamine (Cat. No. 1578-5) that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling (IC₅₀ = 20 nM in the Shh-LIGHT2 assay).

1910 | Cyclopamine-KAAD DataSheet

Alternate Name/Synonyms: 3-Keto-N-(aminoethyl-N’-aminocaproyldihydrocinnamoyl)cyclopamine; KAAD-cyclopamine

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 306387-90-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₄H₆₃N₃O₄

Molecular Weight: 697.99

Cell-Permeable?: Yes

Purity: ≥80% by HPLC

Solubilities: DMSO or EtOH

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Smoothened (Smo) antagonist

MDL Number: MFCD03425585

PubChem CID: 16760383

SMILES: CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC (=O)CCC7=CC=CC=C7

InChi: InChI=1S/C44H63N3O4/c1-29-25-39-42(47(28-29)24-23-46-40(49)13-9-6-10-22- 45-41(50)17-14-32-11-7-5-8-12-32)31(3)44(51-39)21-19-35-36-16-15-33-26- 34(48)18-20-43(33,4)38(36)27-37(35)30(44)2/h5,7-8,11-12,15,29,31,35-36, 38-39,42H,6,9-10,13-14,16-28H2,1-4H3,(H,45,50)(H,46,49)/t29?,31-,35?, 36?,38?,39-,42?,43?,44?/m1/s1

InChi Key: WDHRPWOAMDJICD-BWBMXWGBSA-N