Cyclosporine A | 1522

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B.

Cyclosporine A is a fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B.

1522 | Cyclosporine A DataSheet

Alternate Name/Synonyms: Antibiotic S 7481F1, Cyclosporine

Appearance: White solid

Formulation: N/A

CAS Number: 59865-13-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆₂H₁₁₁N₁₁O₁₂

Molecular Weight: 1202.6

Cell-Permeable?: Yes

Purity: >99%

Solubilities: DMSO and EtOH

Handling: Protect from light and air

Country of Origin: USA

Tag Line: An immunosuppressant

MDL Number: MFCD00274558

PubChem CID: 5284373

SMILES: CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

InChi: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59 (82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChi Key: PMATZTZNYRCHOR-CGLBZJNRSA-N