CYP1B1 polyclonal Antibody | BS5681

CYP1B1 polyclonal Antibody | BS5681 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB ICC

Application Range: WB: 1:500~1:1000 ICC: 1:50~1:200

Background: Cytochrome P450 1B1 (CYP1B1) is a key enzyme involved in the production of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens and is the predominant member of the CYP1 family expressed in normal breast tissue and breast cancer. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE) . CYP1B1 catalyzes the conversion of 17-beta-estradiol to the catechol estrogen metabolites 2-OH-E2 and 4-OH-E2 which have both been postulated to be involved in mammary carcinogenesis. Genetic polymorphisms in CYP1B1 may play an important role in human prostate carcinogenesis as well. Polymorphism of the CYP1B1 gene at codon 432 (Val-->Leu) is associated with a change in catalytic function.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CYP1B1 polyclonal Antibody detects endogenous levels of CYP1B1 protein.

Molecular Weight: ~ 61, 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cytochrome P450 1B1; CYPIB1; CYP1B1

Immunogen: Synthetic peptide, corresponding to amino acids 452-497 of Human CYP1B1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: