CYP27B1 Antibody | 16-876

CYP27B1 Antibody | 16-876 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-195 of human CYP27B1 (NP_000776.1) .

Research Area: Other

Tested Application: WB, IF

Application: WB: 1:500 - 1:2000
IF: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: Rat kidney

Positive Control 2: Rat liver

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 63kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, 1alpha (OH) ase, 25 hydroxyvitamin D3-1-alpha hydroxylase, 25-OHD-1 alpha-hydroxylase, VD3 1A hydroxylase, calcidiol 1-monooxygenase, cytochrome P450 subfamily XXVIIB polypeptide 1, cytochrome P45family 27, subfamily B, polypeptide 1, cytochrome P450C1 alpha, cytochrome P450VD1-alpha, cytochrome p450 27B1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha, 25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.