CYP2J2 polyclonal Antibody | BS5687

CYP2J2 polyclonal Antibody | BS5687 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC ICC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200

Background: CYP2J2 (cytochrome P450 2J2), also known as CPJ2, is a member of the cytochrome P450 protein superfamily. Localized to the ER (endoplasmic reticulum) and microsomal membranes, CYP2J2 is one of three cytochrome P450 enzymes that are responsible for metabolizing arachidonic acid to epoxyeicosatrienoic acids. Functioning via an NADPH-dependent olefin epoxidation, CYP2J2 epoxidizes endogenous cardiac arachidonic acid pools to four different isoforms of epoxyeicosatrienoic acid, all of which are important regulators of cardiovascular homeostasis and vascular tone. CYP2J2 is highly expressed in the heart with low levels of expression found in the liver, colon and kidneys. Up-regulation of CYP2J2 by a c-Jun responsive pathway is thought to promote the neoplastic phenotype of certain carcinoma cells, implicating CYP2J2 in carcinogenesis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CYP2J2 polyclonal Antibody detects endogenous levels of CYP2J2 protein.

Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cytochrome P450 2J2; Arachidonic acid epoxygenase; CYPIIJ2

Immunogen: Synthetic peptide, corresponding to amino acids 270-315 of Human CYP2J2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: