Cystamine dihydrochloride | B2982

Cystamine is an organic disulfide that inhibits transglutaminase (TGM2) with 44% inhibition observed at a concentration of 2.5 mM. It shows neuroprotective activity in a mouse model of Huntington’s disease. It has an anti-inflammatory effect and reduces severity of colitis in a rat model of inflammatory bowel disease.

Cystamine is an organic disulfide that inhibits transglutaminase (TGM2) with 44% inhibition observed at a concentration of 2.5 mM. It shows neuroprotective activity in a mouse model of Huntington’s disease. It has an anti-inflammatory effect and reduces severity of colitis in a rat model of inflammatory bowel disease.

B2982 | Cystamine dihydrochloride DataSheet

Alternate Name/Synonyms: 2,2'-Disulfanediyldiethanamine dihydrochloride; Ethanamine, 2,2'-dithiobis-, dihydrochloride; Cystamin dihydrochloride; 2-(2-aminoethyldisulfanyl)ethanamine, dihydrochloride; 2,2'-Diaminodiethyl disulfide dihydrochloride

Appearance: Solid

Formulation:

CAS Number: 56-17-7

Structure Available?: True

Peptide sequence:

Salt Form: yes

Molecular Formula: C₄H₁₄Cl₂N₂S₂

Molecular Weight: 225.2

Cell-Permeable?: True

Purity: 97%

Solubilities: ~5 mg/ml in in DMSO, ~10 mg/ml in PBS, pH 7.2 in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A transglutaminase inhibitor

MDL Number:

PubChem CID: 5941

SMILES: C(CSSCCN)N.Cl.Cl

InChi: InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H

InChi Key: YUFRRMZSSPQMOS-UHFFFAOYSA-N