Cyt387 | 2316

Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ values of 11 nM and 18 nM, respectively. Inhibits JAK3 at much higher concentrations (IC₅₀ = 155 nM).

Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ values of 11 nM and 18 nM, respectively. Inhibits JAK3 at much higher concentrations (IC₅₀ = 155 nM).

2316 | Cyt387 DataSheet

Alternate Name/Synonyms: (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-l)-benzamide; CYT11387

Appearance: Yellow to light orange solid

Formulation: N/A

CAS Number: 1056634-68-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₂N₆O₂

Molecular Weight: 414.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~80 mg/ml) or Ethanol (<1 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent JAK1 and JAK2 inhibitor

MDL Number: MFCD16038899

PubChem CID: 25062766

SMILES: C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N

InChi: InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)

InChi Key: ZVHNDZWQTBEVRY-UHFFFAOYSA-N