CYTH2 Antibody | 22-647

CYTH2 Antibody | 22-647 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 150-350 of human CYTH2 (NP_059431.1) .

Research Area: Cell Cycle, Signal Transduction

Tested Application: WB, IF

Application: WB: 1:500 - 1:2000
IF: 1:50 - 1:100

Specificiy: N/A

Positive Control 1: A-549

Positive Control 2: MCF7

Positive Control 3: HepG2

Positive Control 4: Mouse ovary

Positive Control 5: Rat brain

Positive Control 6: N/A

Molecular Weight: Observed: 47kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) , ARNO, CTS18, CTS18.1, PSCD2L, SEC7L, Sec7p-L, Sec7p-like, ARF exchange factor, ARF nucleotide-binding site opener, cytohesin 2, pleckstrin homology, Sec7 and coiled-coil domains 2-like, PSCD2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.