Cytochalasin D | B1176

Cytochalasin D is a cell-permeable fungal toxin that acts as a potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways. It is about 10-fold more effective than Cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K⁺ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+levels. Exhibits antitumor activity. Induces apoptosis.

Cytochalasin D is a cell-permeable fungal toxin that acts as a potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways. It is about 10-fold more effective than Cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K⁺ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+levels. Exhibits antitumor activity. Induces apoptosis.

B1176 | Cytochalasin D DataSheet

Alternate Name/Synonyms: Zygosporin A

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 22144-77-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₃₀H₃₇NO₆

Molecular Weight: 507.6

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of actin polymerization

MDL Number: MFCD00077706

PubChem CID: 5458428

SMILES: CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O

InChi: InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

InChi Key: SDZRWUKZFQQKKV-JHADDHBZSA-N