Cytochrome P450 2D6, human recombinant | 7870

Cytochrome P450 2D6 is a member of a family of microsomal enzymes (mono-oxygenases) present in the endoplasmic reticulum membrane, which detoxify xenobiotic compounds. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1) which has been classically studied by immunofluorescence microscopy. The presence of these autoantibodies is considered indicative of Autoimmune Hepatitis Type 2; LKM 1 antibodies have also been detected in patients with hepatitis C viral infection. The use of a purified recombinant Cytochrome P450 2D6 antigen allows the differentiation of autoimmune hepatitis from drug-induced hepatitis where transient autoantibodies to other P450 family members occur which cannot be differentiated by immunofluorescence techniques.

7870 | Cytochrome P450 2D6 human recombinant DataSheet

Biomolecule/Target: Cytochrome P450 2D6

Synonyms: Cytochrome P450 2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1

Alternates names: apm-1, Adipolean , 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein, ADIPOQ, ACDC, ACRP30, APM1, GBP28

Taglines: Human recombinant Cytochrome P450 2D6 from Sf9 cells can be used to screen human autoantibodies (autoimmune hepatitis), in ELISA assays, Western Blots and more

NCBI Gene ID #: 9370

NCBI Gene Symbol: ADIPOQ

Gene Source: BPIHuman

Accession #: NM_004797

Recombinant: Yes

Source: Sf9 Insect cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to inhibit the proliferation of murine myeloid cell lines M1. The ED for this effect is < 1-3 µg/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 16.6 kDa

Concentration: Lot specific

Appearance: Liquid

Physical form description: Sterile filtered, 50 mM Potassium phosphate buffer pH 7.5, 15% glycerol, 1 mM DTT and 1% Triton X-100

Reconstitution Instructions: Reconstitute Adiponectin/ gACRP30 protein in water to a concentration of 1 mg/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A