Cytokeratin 14 polyclonal Antibody | BS90376

Cytokeratin 14 polyclonal Antibody | BS90376 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC

Application Range: WB:1:1,000-1:2,000 ICC:1:100-1:500 IHC:1:100-1:500

Background: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Cytokeratin 14 polyclonal Antibody detects endogenous levels of Cytokeratin 14 protein.

Molecular Weight: 53 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CK-14, K14, KRT14, CK 14, CK-14, ck14, Cytokeratin 14, Cytokeratin-14, Cytokeratin14, Dowling Meara, EBS3, EBS4, Epidermolysis bullosa simplex, K14, K1C14, Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner), Keratin 14, Keratin, Keratin type I cytoskeletal 14, Keratin, type I cytoskeletal 14, Keratin-14, Keratin14, Koebner, Krt 14, Krt14, NFJ, OTTHUMP00000164624, type I cytoskeletal 14,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: