Cytokeratin 18 monoclonal Antibody | MB0146

Cytokeratin 18 monoclonal Antibody | MB0146 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human,Monkey

Application: WB ICC

Application Range: WB: 1:500~2000 ICC: 1:200~1000

Background: Cytokeratin 18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6) -mediated barrier protection.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of Cytokeratin 18 and does not cross-react with related proteins

Molecular Weight: Predicted band size:46KDa Observed band size:46KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; Short name=CK-18; Keratin-18; Short name=K18; KRT18; CYK18; PIG46; KRT 18; CK 18; CK18; Keratin 18; Keratin18; CK-18

Immunogen: Recombinant full length Human Cytokeratin 18.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Epigenetic Writers and Erasers of Histone H3,