Cytokeratin 19 Antibody [SB39g] (HRP) | 99-634

Cytokeratin 19 Antibody [SB39g] (HRP) | 99-634 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: Recombinant C-terminal cytokeratin 19

Research Area: Signal Transduction

Tested Application: Flow

Application: Cytokeratin 19 Antibody [SB39g] for use in immunocytochemistry, ELISA, and western blotting assays.

Specificiy: Cytokeratin 19

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [SB39g]

Isotype: IgG2a

Conjugate: HRP

Physical State: Liquid

Buffer: Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added

Concentration: Lot specific

Storage Condition: Store vial at 2-8˚C

Alternate Name: CK 19, keratin 19

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8) . The two keratin types share only 30% sequence homology. Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin. It is found in many simple and some non-keratinizing stratified squamous epithelia and is often co-expressed with keratin 7. Cytokeratin 19 has been implicated as a marker for stem cells in some tissues such as hair follicles in the skin. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers.